Article
The role of autophagy in host defence against Mycobacterium tuberculosis infection.
Tuberculosis (Edinburgh, Scotland) - 1 Sept 2012
Songane Mário, Kleinnijenhuis Johanneke, Netea Mihai G, van Crevel Reinout
Abstract excerpt
Autophagy is a vital homeostatic process triggered by starvation and other cellular stresses, in which cytoplasmatic cargo is targeted for degradation in specialized structures termed autophagosomes. Autophagy is involved in nutrient regeneration, protein and organelle degradation, but also in clearance of intracellular pathogens such as Mycobacterium tuberculosis, the causative agent of tuberculosis. Recent...
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