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Article

Polymorphic allele of human IRGM1 is associated with susceptibility to tuberculosis in African Americans.

PloS one - 21 Jan 2011

King Katherine Y, Lew Justin D, Ha Ngan P, Lin Jeffery S, Ma Xin, Graviss Edward A, Goodell Margaret A

Abstract excerpt

An ancestral polymorphic allele of the human autophagy-related gene IRGM1 is associated with altered gene expression and a genetic risk for Crohn's Disease (CD). We used the single nucleotide polymorphism rs10065172C/T as a marker of this polymorphic allele and genotyped 370 African American and 177 Caucasian tuberculosis (TB) cases and 180 African American and 110 Caucasian controls. Among African Americans, the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21283700
DOI: 10.1371/journal.pone.0016317
PMCID: PMC3025014

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