Article
Investigating the viability of genetic screening/testing for RA susceptibility using combinations of five confirmed risk loci.
Rheumatology (Oxford, England) - 1 Nov 2009
McClure Annie, Lunt Mark, Eyre Steve, Ke Xiayi, Thomson Wendy, Hinks Anne, Bowes John, Gibbons Laura, Plant Darren, Wilson Anthony G, Marinou Ioanna, Morgan Ann W, Emery Paul, Steer Sophia, Hocking Lynne J, Reid David M, Wordsworth Paul, Harrison Pille, Worthington Jane, Barton Anne
Abstract excerpt
OBJECTIVE: Five loci-the shared epitope (SE) of HLA--DRB1, the PTPN22 gene, a locus on 6q23, the STAT4 gene and a locus mapping to the TRAF1/C5 genetic region--have now been unequivocally confirmed as conferring susceptibility to RA. The largest single effect is conferred by SE. We hypothesized that combinations of susceptibility alleles may increase risk over and above that of any individual locus alone....
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