Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cumulative association of 22 genetic variants with seropositive rheumatoid arthritis risk.

Annals of the rheumatic diseases - 1 Jun 2010

Karlson Elizabeth W, Chibnik Lori B, Kraft Peter, Cui Jing, Keenan Brendan T, Ding Bo, Raychaudhuri Souyma, Klareskog Lars, Alfredsson Lars, Plenge Robert M

Abstract excerpt

BACKGROUND: Recent discoveries of risk alleles have made it possible to define genetic risk profiles for patients with rheumatoid arthritis (RA). This study examined whether a cumulative score based on 22 validated genetic risk alleles for seropositive RA would identify high-risk, asymptomatic individuals who might benefit from preventive interventions. METHODS: Eight human leucocyte antigen (HLA) alleles and 14...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Arthritis, Rheumatoid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Autoantibodies

Share to Epidemiologic Methods

Share to Gene Frequency

Share to Genetic Predisposition to Disease

Share to Peptides, Cyclic

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 20233754
DOI: 10.1136/ard.2009.120170
PMCID: PMC2933175

Genes

NHS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cumulative association of 22 genetic variants with seropositive rheumatoid arthritis risk.PMID 20233754Read ↗

A weighted genetic risk score using all known susceptibility variants to estimate rheumatoid arthritis risk.Semantic proximity Read ↗

Genetic risk score predicting risk of rheumatoid arthritis phenotypes and age of symptom onset.Semantic proximity Read ↗

Genetic risk scores and number of autoantibodies in patients with rheumatoid arthritis.Semantic proximity Read ↗

Improved performance of epidemiologic and genetic risk models for rheumatoid arthritis serologic phenotypes using family history.Semantic proximity Read ↗

Association of environmental and genetic factors and gene-environment interactions with risk of developing rheumatoid arthritis.Semantic proximity Read ↗

The genetic architecture of rheumatoid arthritis: from susceptibility to clinical subphenotype associations.Semantic proximity Read ↗

Genetics of rheumatoid arthritis: what have we learned?Semantic proximity Read ↗

Genetic markers of rheumatoid arthritis susceptibility in anti-citrullinated peptide antibody negative patients.Semantic proximity Read ↗

A genome-wide association study of rheumatoid arthritis without antibodies against citrullinated peptides.Semantic proximity Read ↗

Quantitative heritability of anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis.Semantic proximity Read ↗

Strong combined gene-environment effects in anti-cyclic citrullinated peptide-positive rheumatoid arthritis: a nationwide case-control study in Denmark.Semantic proximity Read ↗

The HLA-DRB1 shared epitope alleles are primarily a risk factor for anti-cyclic citrullinated peptide antibodies and are not an independent risk factor for development of rheumatoid arthritis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.