Lack of replication of interactions between polymorphisms in rheumatoid arthritis susceptibility: case-control study.

doi:10.1186/s13075-014-0436-x

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Article

Lack of replication of interactions between polymorphisms in rheumatoid arthritis susceptibility: case-control study.

Arthritis research & therapy - 27 Sept 2014

Ferreiro-Iglesias Aida, Calaza Manuel, Perez-Pampin Eva, Lopez Longo Francisco J, Marenco Jose L, Blanco Francisco J, Narvaez Javier, Navarro Federico, Cañete Juan D, de la Serna Arturo R, Gonzalez-Alvaro Isidoro, Herrero-Beaumont Gabriel, Pablos Jose L, Balsa Alejandro, Fernandez-Gutierrez Benjamin, Caliz Rafael, Gomez-Reino Juan J, Gonzalez Antonio

Abstract excerpt

INTRODUCTION: Approximately 100 loci have been definitively associated with rheumatoid arthritis (RA) susceptibility. However, they explain only a fraction of RA heritability. Interactions between polymorphisms could explain part of the remaining heritability. Multiple interactions have been reported, but only the shared epitope (SE) × protein tyrosine phosphatase nonreceptor type 22 (PTPN22) interaction has been...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25260880
DOI: 10.1186/s13075-014-0436-x
PMCID: PMC4207328

Genes

PTPN22
GSTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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