A Combination of CD28 (rs1980422) and IRF5 (rs10488631) Polymorphisms Is Associated with Seropositivity in Rheumatoid Arthritis: A Case Control Study.

doi:10.1371/journal.pone.0153316

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Article

A Combination of CD28 (rs1980422) and IRF5 (rs10488631) Polymorphisms Is Associated with Seropositivity in Rheumatoid Arthritis: A Case Control Study.

PloS one - 1 Jan 2016

Vernerova Lucia, Spoutil Frantisek, Vlcek Miroslav, Krskova Katarina, Penesova Adela, Meskova Milada, Marko Andrea, Raslova Katarina, Vohnout Branislav, Rovensky Jozef, Killinger Zdenko, Jochmanova Ivana, Lazurova Ivica, Steiner Guenter, Smolen Josef, Imrich Richard

Abstract excerpt

INTRODUCTION: The aim of the study was to analyse genetic architecture of RA by utilizing multiparametric statistical methods such as linear discriminant analysis (LDA) and redundancy analysis (RDA). METHODS: A total of 1393 volunteers, 499 patients with RA and 894 healthy controls were included in the study. The presence of shared epitope (SE) in HLA-DRB1 and 11 SNPs (PTPN22 C/T (rs2476601), STAT4 G/T...

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Identifiers

PMID: 27092776
DOI: 10.1371/journal.pone.0153316
PMCID: PMC4836711

Genes

AFF3
CTLA4
PADI4
PTPN22
STAT4
CSK
TNFAIP3
TRAF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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