Article
Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset.
Annals of the rheumatic diseases - 1 Aug 2022
Saevarsdottir Saedis, Stefansdottir Lilja, Sulem Patrick, Thorleifsson Gudmar, Ferkingstad Egil, Rutsdottir Gudrun, Glintborg Bente, Westerlind Helga, Grondal Gerdur, Loft Isabella C, Sorensen Signe Bek, Lie Benedicte A, Brink Mikael, Ärlestig Lisbeth, Arnthorsson Asgeir Orn, Baecklund Eva, Banasik Karina, Bank Steffen, Bjorkman Lena I, Ellingsen Torkell, Erikstrup Christian, Frei Oleksandr, Gjertsson Inger, Gudbjartsson Daniel F, Gudjonsson Sigurjon A, Halldorsson Gisli H, Hendricks Oliver, Hillert Jan, Hogdall Estrid, Jacobsen Søren, Jensen Dorte Vendelbo, Jonsson Helgi, Kastbom Alf, Kockum Ingrid, Kristensen Salome, Kristjansdottir Helga, Larsen Margit H, Linauskas Asta, Hauge Ellen-Margrethe, Loft Anne G, Ludviksson Bjorn R, Lund Sigrun H, Markusson Thorsteinn, Masson Gisli, Melsted Pall, Moore Kristjan H S, Munk Heidi, Nielsen Kaspar R, Norddahl Gudmundur L, Oddsson Asmundur, Olafsdottir Thorunn A, Olason Pall I, Olsson Tomas, Ostrowski Sisse Rye, Hørslev-Petersen Kim, Rognvaldsson Solvi, Sanner Helga, Silberberg Gilad N, Stefansson Hreinn, Sørensen Erik, Sørensen Inge J, Turesson Carl, Bergman Thomas, Alfredsson Lars, Kvien Tore K, Brunak Søren, Steinsson Kristján, Andersen Vibeke, Andreassen Ole A, Rantapää-Dahlqvist Solbritt, Hetland Merete Lund, Klareskog Lars, Askling Johan, Padyukov Leonid, Pedersen Ole Bv, Thorsteinsdottir Unnur, Jonsdottir Ingileif, Stefansson Kari
Abstract excerpt
OBJECTIVES: To find causal genes for rheumatoid arthritis (RA) and its seropositive (RF and/or ACPA positive) and seronegative subsets. METHODS: We performed a genome-wide association study (GWAS) of 31 313 RA cases (68% seropositive) and ~1 million controls from Northwestern Europe. We searched for causal genes outside the HLA-locus through effect on coding, mRNA expression in several tissues and/or levels of...
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