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Article

Validation of a Genetic Risk Score Combined With Clinical Variables for Predicting Pulmonary Fibrosis in Early Rheumatoid Arthritis.

Arthritis care & research - 1 Jun 2026

Brink Mikael, Wheeler Austin, England Bryant R, Rantapää-Dahlqvist Solbritt

Abstract excerpt

OBJECTIVE: Pulmonary fibrosis (PF) is a severe extra-articular manifestation of rheumatoid arthritis (RA). This study aimed to externally validate a genetic risk score (GRS) and a combined risk score (CRS) for predicting the risk of RA-associated PF in an independent cohort of patients with early RA. METHODS: This study used an inception cohort of 1,118 patients diagnosed with RA from northern Sweden between 1996...

Topics

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Arthritis, Rheumatoid
Genetic Risk Score
GTPase-Activating Proteins
Mucin-5B
Predictive Value of Tests

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pulmonary Fibrosis

Risk Assessment

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Open in PubMed Open full text

Identifiers

PMID: 41236136
DOI: 10.1002/acr.25696
PMCID: PMC13206375

Genes

FAM13A
MUC5B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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