Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers.

doi:10.1136/ard.2009.121020

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Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers.

Annals of the rheumatic diseases - 1 Aug 2010

Plant Darren, Flynn Edward, Mbarek Hamdi, Dieudé Philippe, Cornelis François, Arlestig Lisbeth, Dahlqvist Solbritt Rantapää, Goulielmos George, Boumpas Dimitrios T, Sidiropoulos Prodromos, Johansen Julia S, Ørnbjerg Lykke M, Hetland Merete Lund, Klareskog Lars, Filer Andrew, Buckley Christopher D, Raza Karim, Witte Torsten, Schmidt Reinhold E, Worthington Jane

Abstract excerpt

BACKGROUND: Genetic factors have a substantial role in determining development of rheumatoid arthritis (RA), and are likely to account for 50-60% of disease susceptibility. Genome-wide association studies have identified non-human leucocyte antigen RA susceptibility loci which associate with RA with low-to-moderate risk. OBJECTIVES: To investigate recently identified RA susceptibility markers using cohorts from...

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Identifiers

PMID: 20498205
DOI: 10.1136/ard.2009.121020
PMCID: PMC2938898

Genes

AFF3
CTLA4
PTPN22
STAT4
TRAF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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