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New mutant versions of yeast FACT subunit Spt16 affect cell integrity.

Molecular genetics and genomics : MGG - 1 Nov 2009

O'Donnell Allyson F, Stevens Jennifer R, Kepkay Rosemarie, Barnes Christine A, Johnston Gerald C, Singer Richard A

Abstract excerpt

Transcription by RNA polymerase II is impeded by the nucleosomal organization of DNA; these negative effects are modulated at several stages of nucleosomal DNA transcription by FACT, a heterodimeric transcription factor. At promoters, FACT facilitates the binding of TATA-binding factor, while during transcription elongation FACT mediates the necessary destabilization of nucleosomes and subsequent restoration of...

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PMID: 19727824
DOI: 10.1007/s00438-009-0480-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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New mutant versions of yeast FACT subunit Spt16 affect cell integrity.PMID 19727824Read ↗

Mutant versions of the S. cerevisiae transcription elongation factor Spt16 define regions of Spt16 that functionally interact with histone H3.Semantic proximity Read ↗

Insight into the mechanism of nucleosome reorganization from histone mutants that suppress defects in the FACT histone chaperone.Semantic proximity Read ↗

FACT, the Bur kinase pathway, and the histone co-repressor HirC have overlapping nucleosome-related roles in yeast transcription elongation.Semantic proximity Read ↗

The chromatin-specific transcription elongation factor FACT comprises human SPT16 and SSRP1 proteins.Semantic proximity Read ↗

The yeast FACT complex has a role in transcriptional initiation.Semantic proximity Read ↗

Domain organization of the yeast histone chaperone FACT: the conserved N-terminal domain of FACT subunit Spt16 mediates recovery from replication stress.Semantic proximity Read ↗

A nucleosomal region important for ensuring proper interactions between the transcription elongation factor Spt16 and transcribed genes in Saccharomyces cerevisiae.Semantic proximity Read ↗

Essential histone chaperones collaborate to regulate transcription and chromatin integrity.Semantic proximity Read ↗

The Histone Chaperone FACT Contributes to DNA Replication-Coupled Nucleosome Assembly.Semantic proximity Read ↗

Charged residues on the side of the nucleosome contribute to normal Spt16-gene interactions in budding yeast.Semantic proximity Read ↗

Evidence that the localization of the elongation factor Spt16 across transcribed genes is dependent upon histone H3 integrity in Saccharomyces cerevisiae.Semantic proximity Read ↗

Noncoding Transcription Is a Driving Force for Nucleosome Instability in spt16 Mutant Cells.Semantic proximity Read ↗

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