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Article

Essential histone chaperones collaborate to regulate transcription and chromatin integrity.

Genes & development - 1 May 2021

Viktorovskaya Olga, Chuang James, Jain Dhawal, Reim Natalia I, López-Rivera Francheska, Murawska Magdalena, Spatt Dan, Churchman L Stirling, Park Peter J, Winston Fred

Abstract excerpt

Histone chaperones are critical for controlling chromatin integrity during transcription, DNA replication, and DNA repair. Three conserved and essential chaperones, Spt6, Spn1/Iws1, and FACT, associate with elongating RNA polymerase II and interact with each other physically and/or functionally; however, there is little understanding of their individual functions or their relationships with each other. In this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33888559
DOI: 10.1101/gad.348431.121
PMCID: PMC8091981

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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