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Article

Noncoding Transcription Is a Driving Force for Nucleosome Instability in spt16 Mutant Cells.

Molecular and cellular biology - 1 Jul 2016

Feng Jianxun, Gan Haiyun, Eaton Matthew L, Zhou Hui, Li Shuqi, Belsky Jason A, MacAlpine David M, Zhang Zhiguo, Li Qing

Abstract excerpt

FACT (facilitates chromatin transcription) consists of two essential subunits, Spt16 and Pob3, and functions as a histone chaperone. Mutation of spt16 results in a global loss of nucleosomes as well as aberrant transcription. Here, we show that the majority of nucleosome changes upon Spt16 depletion are alterations in nucleosome fuzziness and position shift. Most nucleosomal changes are suppressed by the...

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Identifiers

PMID: 27141053
DOI: 10.1128/MCB.00152-16
PMCID: PMC4911744

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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