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Article

The chromatin-specific transcription elongation factor FACT comprises human SPT16 and SSRP1 proteins.

Nature - 15 Jul 1999

Orphanides G, Wu W H, Lane W S, Hampsey M, Reinberg D

Abstract excerpt

The regulation of gene expression depends critically upon chromatin structure. Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. This minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. Two classes of accessory factor, ATP-dependent...

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Source

Identifiers

PMID: 10421373
DOI: 10.1038/22350

Genes

SSRP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The chromatin-specific transcription elongation factor FACT comprises human SPT16 and SSRP1 proteins.PMID 10421373Read ↗

Mutant versions of the S. cerevisiae transcription elongation factor Spt16 define regions of Spt16 that functionally interact with histone H3.Semantic proximity Read ↗

FACT, the Bur kinase pathway, and the histone co-repressor HirC have overlapping nucleosome-related roles in yeast transcription elongation.Semantic proximity Read ↗

The FACT chromatin modulator: genetic and structure/function relationships.Semantic proximity Read ↗

Domain organization of the yeast histone chaperone FACT: the conserved N-terminal domain of FACT subunit Spt16 mediates recovery from replication stress.Semantic proximity Read ↗

New mutant versions of yeast FACT subunit Spt16 affect cell integrity.Semantic proximity Read ↗

The Histone Chaperone FACT Contributes to DNA Replication-Coupled Nucleosome Assembly.Semantic proximity Read ↗

Essential histone chaperones collaborate to regulate transcription and chromatin integrity.Semantic proximity Read ↗

The yeast FACT complex has a role in transcriptional initiation.Semantic proximity Read ↗

A nucleosomal region important for ensuring proper interactions between the transcription elongation factor Spt16 and transcribed genes in Saccharomyces cerevisiae.Semantic proximity Read ↗

Insight into the mechanism of nucleosome reorganization from histone mutants that suppress defects in the FACT histone chaperone.Semantic proximity Read ↗

Spt16-Pob3 and the HMG protein Nhp6 combine to form the nucleosome-binding factor SPN.Semantic proximity Read ↗

Defects in SPT16 or POB3 (yFACT) in Saccharomyces cerevisiae cause dependence on the Hir/Hpc pathway: polymerase passage may degrade chromatin structure.Semantic proximity Read ↗

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