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Structural and Functional Studies of trans-Encoded HLA-DQ2.3 (DQA103:01/DQB102:01) Protein Molecule

24 Feb 2012

Abstract excerpt

MHC class II molecules are composed of one α-chain and one β-chain whose membrane distal interface forms the peptide binding groove. Most of the existing knowledge on MHC class II molecules comes from the cis-encoded variants where the α- and β-chain are encoded on the same chromosome. However, trans-encoded class II MHC molecules, where the α- and β-chain are encoded on opposite chromosomes, can also be...

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PMID: 22362761
DOI: 10.1074/jbc.m111.320374

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