Article
Functional consequences of HLA-DQ8 homozygosity versus heterozygosity for islet autoimmunity in type 1 diabetes.
Genes and immunity - 1 Sept 2011
Eerligh P, van Lummel M, Zaldumbide A, Moustakas A K, Duinkerken G, Bondinas G, Koeleman B P C, Papadopoulos G K, Roep B O
Abstract excerpt
Human leukocyte antigen (HLA) class II haplotypes are established risk factors in type 1 diabetes (T1D). The heterozygous DQ2/8 genotype confers the highest risk, whereas the DQ6/8 genotype is protective. We hypothesized that DQ2/8 trans-molecules composed of α and β chains from DQ2 and DQ8 express unique β-cell epitopes, whereas DQ6 may interfere with peptide binding to DQ8. Here we show that a single insulin...
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