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Article

Trans heterodimer between two non-arthritis-associated HLA alleles can predispose to arthritis in humanized mice.

Arthritis and rheumatism - 1 Jun 2011

Behrens Marshall, Papadopoulos George K, Moustakas Antonis, Smart Michele, Luthra Harvinder, David Chella S, Taneja Veena

Abstract excerpt

OBJECTIVE: Certain HLA class II alleles are associated with susceptibility to the development of arthritis. However, the development of arthritis in some persons carrying non-rheumatoid arthritis (RA)-associated alleles remains unexplained. An individual who is heterozygous for the DQA1 and DQB1 genes can express the DQ molecule in cis or trans heterodimers. In a cis heterodimer, the α-chain interacts with the...

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Identifiers

PMID: 21305521
DOI: 10.1002/art.30260
PMCID: PMC3106136

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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