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A predisposing effect of HLA class II genes in celiac disease by skewing the naïve CD4 <sup>+</sup> T-cell receptor repertoire

2025-07-18

Abstract excerpt

Polymorphisms of human leukocyte antigen (HLA) genes confer risks for many human diseases. For predisposing effects relating to T-cell receptor (TCR) recognition of peptide-HLA, the effect can be both selection of the TCR repertoire and preferential presentation of disease-driving epitopes. In celiac disease (CeD) HLA-DQ2.5 predisposes by presenting deamidated gluten peptides to CD4 + T cells that typically emplo...

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Literature Corpus work
b6a8c3ca-bc82-5988-82e9-3000dc4551f7
DOI
10.1101/2025.07.15.663863
Open publication

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A predisposing effect of HLA class II genes in celiac disease by skewing the naïve CD4 <sup>+</sup> T-cell receptor repertoireDOI 10.1101/2025.07.15.663863
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