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Article

Differential expression of predisposing HLA-DQ2.5 alleles in DR5/DR7 celiac disease patients affects the pathological immune response to gluten.

Scientific reports - 14 Oct 2020

Pisapia Laura, Picascia Stefania, Farina Federica, Barba Pasquale, Gianfrani Carmen, Del Pozzo Giovanna

Abstract excerpt

The DR5-DQ7/DR7-DQ2 genotype is very frequent among patients affected by celiac disease (CD), in Europe. This genotype, associated to high risk of CD, carries the HLA-DQA1*05 and HLA-DQB1*02 predisposing alleles, in trans configuration. The alleles encode the DQ2.5 heterodimer responsible of gluten peptide presentation on the surface of antigen-presenting cells (APCs), and consequent pathogenic CD4+ T cell...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to CD4-Positive T-Lymphocytes

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Share to Receptors, TNF-Related Apoptosis-Inducing Ligand

Source

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Identifiers

PMID: 33057065
DOI: 10.1038/s41598-020-73907-2
PMCID: PMC7560598

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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