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Article

Type 1 diabetes-associated HLA-DQ8 transdimer accommodates a unique peptide repertoire.

The Journal of biological chemistry - 16 Mar 2012

van Lummel Menno, van Veelen Peter A, Zaldumbide Arnaud, de Ru Arnoud, Janssen George M C, Moustakas Antonis K, Papadopoulos George K, Drijfhout Jan W, Roep Bart O, Koning Frits

Abstract excerpt

HLA-DQ2 and HLA-DQ8 are strongly predisposing haplotypes for type 1 diabetes (T1D). Yet HLA-DQ2/8 heterozygous individuals have a synergistically increased risk compared with HLA-DQ2 or HLA-DQ8 homozygote subjects that may result from the presence of a transdimer formed between the α-chain of HLA-DQ2 (DQA1*05:01) and the β-chain of HLA-DQ8 (DQB1*03:02). We generated cells exclusively expressing this transdimer...

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Identifiers

PMID: 22184118
DOI: 10.1074/jbc.M111.313940
PMCID: PMC3308765

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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