Article
Tissue-specific transformation by oncogenic mutants of epidermal growth factor receptor.
Critical reviews in oncogenesis - 1 Jan 1994
Carter T H, Kung H J
Abstract excerpt
Mutations in the receptor for the epidermal growth factor provide valuable insight into mechanisms of growth control. Oncogenic mutants of this receptor tyrosine kinase cause erythroid leukemia, fibrosarcoma, angiosarcoma, glioblastoma, and melanoma. Mutations in the avian protooncogene occur by retroviral mechanisms. Deletion of the ligand-binding domain results in erythroblastosis, while additional mutations in...
Topics
- Animals
- Cell Transformation, Neoplastic
- ErbB Receptors
- Erythroblasts
- Humans
- Mitosis
- Mutation
- Organ Specificity