Article
Th2 cell-selective enhancement of human IL13 transcription by IL13-1112C>T, a polymorphism associated with allergic inflammation.
Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2006
Cameron Lisa, Webster Robin B, Strempel Jannine M, Kiesler Patricia, Kabesch Michael, Ramachandran Harikrishnan, Yu Lizhi, Stern Debra A, Graves Penelope E, Lohman I Carla, Wright Anne L, Halonen Marilyn, Klimecki Walter T, Vercelli Donata
Abstract excerpt
IL-13 is a central mediator of allergic inflammation. The single nucleotide polymorphism IL13-1112C>T (rs1800925) is associated with allergic phenotypes in ethnically distinct populations, but the underlying mechanism(s) remain unknown. Using in vivo, in vitro, and in silico analysis, we show that the IL13-1112T allele enhanced IL13 promoter activity in primary human and murine CD4(+) Th2 lymphocytes. Increased...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.