Article
An IL-13 promoter polymorphism associated with increased risk of allergic asthma.
Genes and immunity - 1 Sept 1999
van der Pouw Kraan T C, van Veen A, Boeije L C, van Tuyl S A, de Groot E R, Stapel S O, Bakker A, Verweij C L, Aarden L A, van der Zee J S
Abstract excerpt
IL-13 plays a crucial role in the development of allergic asthma by several mechanisms, including induction of IgE antibodies, airway eosinophilia and hyper-reactivity. We previously established a deregulated production of IL-13 by T cells from allergic asthma patients. In this report we describe the identification of a novel IL-13 promoter polymorphism (C to T exchange) at position -1055. The IL-13 -1055 TT...
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