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Article

IL-13 R130Q, a common variant associated with allergy and asthma, enhances effector mechanisms essential for human allergic inflammation.

The Journal of clinical investigation - 1 Mar 2005

Vladich Frank D, Brazille Susan M, Stern Debra, Peck Michael L, Ghittoni Raffaella, Vercelli Donata

Abstract excerpt

Genetic factors are known to strongly influence susceptibility to allergic inflammation. The Th2 cytokine IL-13 is a central mediator of allergy and asthma, and common single-nucleotide polymorphisms in IL13 are associated with allergic phenotypes in several ethnically diverse populations. In particular, IL13+2044GA is expected to result in the nonconservative replacement of arginine 130 (R130) with glutamine...

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Identifiers

PMID: 15711639
DOI: 10.1172/JCI22818
PMCID: PMC548315

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STAT6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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