Article
Patterns of GATA3 and IL13 gene polymorphisms associated with childhood rhinitis and atopy in a birth cohort.
The Journal of allergy and clinical immunology - 1 Feb 2008
Huebner Marianne, Kim Dong-Yun, Ewart Susan, Karmaus Wilfried, Sadeghnejad Alireza, Arshad Syed H
Abstract excerpt
BACKGROUND: GATA3 activates transcription of the T(H)2 cytokines, including IL13, an important step in the allergic inflammatory pathway. OBJECTIVE: We sought to identify associations of single nucleotide polymorphisms of the genes GATA3 and IL13 and their interactions with rhinitis and allergic sensitization during childhood. METHODS: We performed genetic association studies in a cohort of children (n = 923) who...
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