Article

Targeting a central feature of asthma using a cell type-selective IL-13-responsive enhancer

2021-10-09

Abstract excerpt

IL-13 is a central mediator of asthma 1–3 . Here, we used genome-wide approaches to characterize genes and regulatory elements modulated by IL-13 and other asthma-associated cytokines in airway epithelial cells and showed how they can be used for therapeutic purposes. Using bulk and single cell RNA-seq, we found distinctive responses to IL-13, IL-17, and interferons in human bronchial epithelial basal, ciliated,...

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Literature Corpus work: 25f6005d-ea01-515b-ae14-5ace6ae69900
DOI: 10.1101/2021.10.08.463596

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