Article
Functional CRH variation increases stress-induced alcohol consumption in primates.
Proceedings of the National Academy of Sciences of the United States of America - 25 Aug 2009
Barr Christina S, Dvoskin Rachel L, Gupte Manisha, Sommer Wolfgang, Sun Hui, Schwandt Melanie L, Lindell Stephen G, Kasckow John W, Suomi Stephen J, Goldman David, Higley J Dee, Heilig Markus
Abstract excerpt
Corticotropin-releasing factor (CRF), encoded by the CRH gene, is a key integrator of stress responses, and, as such, CRH gene variation may contribute to individual differences in susceptibility to stress-related pathology. In rhesus macaques, a single nucleotide polymorphism (SNP) is found within the CRH promoter (-248C--> T). Here, we assessed whether this variant influenced stress responding and, because...
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