H2 haplotype at chromosome 17q21.31 protects against childhood sexual abuse-associated risk for alcohol consumption and dependence.

doi:10.1111/j.1369-1600.2009.00181.x

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Article

H2 haplotype at chromosome 17q21.31 protects against childhood sexual abuse-associated risk for alcohol consumption and dependence.

Addiction biology - 1 Jan 2010

Nelson Elliot C, Agrawal Arpana, Pergadia Michele L, Wang Jen C, Whitfield John B, Saccone F Scott, Kern Jason, Grant Julia D, Schrage Andrew J, Rice John P, Montgomery Grant W, Heath Andrew C, Goate Alison M, Martin Nicholas G, Madden Pamela A F

Abstract excerpt

Animal research supports a central role for corticotropin-releasing factor (CRF) in actions of ethanol on brain function. An examination of alcohol consumption in adolescents reported a significant genotype x environment (G x E) interaction involving rs1876831, a corticotropin-releasing hormone receptor 1 (CRHR1) polymorphism, and negative events. CRHR1 and at least four other genes are located at 17q21.31 in an...

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Identifiers

PMID: 19878140
DOI: 10.1111/j.1369-1600.2009.00181.x
PMCID: PMC3068622

Genes

CRHR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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