Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional NPY variation as a factor in stress resilience and alcohol consumption in rhesus macaques.

Archives of general psychiatry - 1 Apr 2010

Lindell Stephen G, Schwandt Melanie L, Sun Hui, Sparenborg Jeffrey D, Björk Karl, Kasckow John W, Sommer Wolfgang H, Goldman David, Higley J Dee, Suomi Stephen J, Heilig Markus, Barr Christina S

Abstract excerpt

CONTEXT: Neuropeptide Y (NPY) counters stress and is involved in neuroadaptations that drive escalated alcohol drinking in rodents. In humans, low NPY expression predicts amygdala response and emotional reactivity. Genetic variation that affects the NPY system could moderate stress resilience and susceptibility to alcohol dependence. OBJECTIVE: To determine whether functional NPY variation influences behavioral...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amygdala
Share to Brain Chemistry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypothalamus

Share to Macaca mulatta

Share to Neuropeptide Y

Share to Resilience, Psychological

Share to Stress, Psychological

Share to Testis

Source

Open in PubMed Open full text

Identifiers

PMID: 20368518
DOI: 10.1001/archgenpsychiatry.2010.23
PMCID: PMC2963624

Genes

NPY

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional NPY variation as a factor in stress resilience and alcohol consumption in rhesus macaques.PMID 20368518Read ↗

Functional CRH variation increases stress-induced alcohol consumption in primates.Semantic proximity Read ↗

Genetic variation in human NPY expression affects stress response and emotion.Semantic proximity Read ↗

Genetic modulation of plasma NPY stress response is suppressed in substance abuse: association with clinical outcomes.Semantic proximity Read ↗

Non-human primate models of alcohol-related phenotypes: the influence of genetic and environmental factors.Semantic proximity Read ↗

Risk and resilience: early manipulation of macaque social experience and persistent behavioral and neurophysiological outcomes.Semantic proximity Read ↗

Early rearing history influences oxytocin receptor epigenetic regulation in rhesus macaques.Semantic proximity Read ↗

OPRM1 gene variation influences hypothalamic-pituitary-adrenal axis function in response to a variety of stressors in rhesus macaques.Semantic proximity Read ↗

CRH haplotype as a factor influencing cerebrospinal fluid levels of corticotropin-releasing hormone, hypothalamic-pituitary-adrenal axis activity, temperament, and alcohol consumption in rhesus macaques.Semantic proximity Read ↗

Human NPY promoter variation rs16147:T>C as a moderator of prefrontal NPY gene expression and negative affect.Semantic proximity Read ↗

Strategies for performing genotype-phenotype association studies in nonhuman primates.Semantic proximity Read ↗

A novel single nucleotide polymorphism of the neuropeptide Y (NPY) gene associated with alcohol dependence.Semantic proximity Read ↗

Heritability and relationship of oxytocin receptor gene variants with social behavior and central oxytocin in colony-reared adult female rhesus macaquesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.