Article
Genotypic variation in the promoter region of the CRH-248 gene interacts with early rearing experiences to disrupt the development of the HPA axis in infant rhesus macaques (Macaca mulatta).
Stress (Amsterdam, Netherlands) - 1 Jan 2024
Wood Elizabeth K, Aston S Andrew, O'Connell Patrick H, Hafen Elia, Skowbo Andrea N, Schwandt Melanie L, Lindell Stephen G, Smith Ellie, Johnson Miranda, Baron Zachary, Gabrielle Natalia, Barr Christina S, Suomi Stephen J, Goldman David, Higley J Dee
Abstract excerpt
Aberrant functioning of the hypothalamic-pituitary-adrenal (HPA) axis is a hallmark of conditions such as depression, anxiety disorders, and post-traumatic stress disorder. Early-life adversity and genetic variation can interaction to disrupt HPA axis regulation, potentially contributing to certain forms of psychopathology. This study employs a rhesus macaque model to investigate how early parental neglect...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.