CRH haplotype as a factor influencing cerebrospinal fluid levels of corticotropin-releasing hormone, hypothalamic-pituitary-adrenal axis activity, temperament, and alcohol consumption in rhesus macaques.

doi:10.1001/archpsyc.65.8.934

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Article

CRH haplotype as a factor influencing cerebrospinal fluid levels of corticotropin-releasing hormone, hypothalamic-pituitary-adrenal axis activity, temperament, and alcohol consumption in rhesus macaques.

Archives of general psychiatry - 1 Aug 2008

Barr Christina S, Dvoskin Rachel L, Yuan Qiaoping, Lipsky Robert H, Gupte Manisha, Hu Xian, Zhou Zhifeng, Schwandt Melanie L, Lindell Stephen G, McKee Megan, Becker Michelle L, Kling Mitchel A, Gold Phillip W, Higley Dee, Heilig Markus, Suomi Stephen J, Goldman David

Abstract excerpt

CONTEXT: Both highly stress-reactive and novelty-seeking individuals are susceptible to alcohol use disorders. Variation in stress reactivity, exploration, and response to novelty have been attributed to differences in corticotropin-releasing hormone (CRH) system function. As such, CRH gene variation may influence risk for alcohol use and dependence. OBJECTIVE: To determine whether CRH variation influences...

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PMID: 18678798
DOI: 10.1001/archpsyc.65.8.934
PMCID: PMC2688441

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