Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alcohol-preferring rats show decreased corticotropin-releasing hormone-2 receptor expression and differences in HPA activation compared to alcohol-nonpreferring rats.

Alcoholism, clinical and experimental research - 1 May 2014

Yong Weidong, Spence John Paul, Eskay Robert, Fitz Stephanie D, Damadzic Ruslan, Lai Dongbing, Foroud Tatiana, Carr Lucinda G, Shekhar Anantha, Chester Julia A, Heilig Markus, Liang Tiebing

Abstract excerpt

BACKGROUND: Corticotropin-releasing hormone (CRH) and urocortins (UCNs) bind to corticotropin-releasing hormone type 2 receptor (CRF2 receptor ), a Gs protein-coupled receptor that plays an important role in modulation of anxiety and stress responses. The Crhr2 gene maps to a quantitative trait locus (QTL) for alcohol preference on chromosome 4 previously identified in inbred alcohol-preferring (iP)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcoholism
Share to Brain Chemistry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Corticosterone

Share to Hypothalamo-Hypophyseal System

Share to Pituitary-Adrenal System

Share to Rats, Inbred Strains

Share to Receptors, Corticotropin-Releasing Hormone

Share to Stress, Psychological

Source

Open in PubMed Open full text

Identifiers

PMID: 24611993
DOI: 10.1111/acer.12379
PMCID: PMC4015136

Genes

CRH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alcohol-preferring rats show decreased corticotropin-releasing hormone-2 receptor expression and differences in HPA activation compared to alcohol-nonpreferring rats.PMID 24611993Read ↗

Variation at the rat Crhr1 locus and sensitivity to relapse into alcohol seeking induced by environmental stress.Semantic proximity Read ↗

Defining the role of corticotropin releasing factor binding protein in alcohol consumptionSemantic proximity Read ↗

CRH haplotype as a factor influencing cerebrospinal fluid levels of corticotropin-releasing hormone, hypothalamic-pituitary-adrenal axis activity, temperament, and alcohol consumption in rhesus macaques.Semantic proximity Read ↗

Functional CRH variation increases stress-induced alcohol consumption in primates.Semantic proximity Read ↗

Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 receptors.Semantic proximity Read ↗

Genetic association of the human corticotropin releasing hormone receptor 1 (CRHR1) with binge drinking and alcohol intake patterns in two independent samples.Semantic proximity Read ↗

Genomic screen for QTLs underlying alcohol consumption in the P and NP rat lines.Semantic proximity Read ↗

Prediction of the risk of comorbid alcoholism in schizophrenia by interaction of common genetic variants in the corticotropin-releasing factor system.Semantic proximity Read ↗

Genetical genomic determinants of alcohol consumption in rats and humans.Semantic proximity Read ↗

A quantitative trait locus for alcohol consumption in selectively bred rat lines.Semantic proximity Read ↗

The Corticotropin-Releasing Factor Family: Physiology of the Stress ResponseSemantic proximity Read ↗

Altered amygdalar CRF release and increased anxiety-like behavior in Sardinian alcohol-preferring rats: a microdialysis and behavioral study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.