Article
SIP1 protein protects cells from DNA damage-induced apoptosis and has independent prognostic value in bladder cancer.
Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 2009
Sayan A Emre, Griffiths Thomas R, Pal Raj, Browne Gareth J, Ruddick Andrew, Yagci Tamer, Edwards Richard, Mayer Nick J, Qazi Hasan, Goyal Sandeep, Fernandez Serena, Straatman Kees, Jones George D D, Bowman Karen J, Colquhoun Alexandra, Mellon J Kilian, Kriajevska Marina, Tulchinsky Eugene
Abstract excerpt
The epithelial-mesenchymal transition (EMT) contributes to cancer metastasis. Two ZEB family members, ZEB1 and ZEB2(SIP1), inhibit transcription of the E-cadherin gene and induce EMT in vitro. However, their relevance to human cancer is insufficiently studied. Here, we performed a comparative study of SIP1 and ZEB1 proteins in cancer cell lines and in one form of human malignancy, carcinoma of the bladder....
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