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Article

Pleiotropic Roles for ZEB1 in Cancer

18 Dec 2017

Abstract excerpt

Abstract ZEB1 is a prime element of a network of transcription factors that controls epithelial-to-mesenchymal transition (EMT), a reversible embryonic transdifferentiation program that allows partial or complete transition from an epithelial to a mesenchymal state. Aberrant expression of ZEB1 has been reported in a variety of human cancers, where it is generally believed to foster migration, invasion, and...

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PMID: 29254997
DOI: 10.1158/0008-5472.can-17-2476

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