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ZEB1 Regulates Multiple Oncogenic Components Involved in Uveal Melanoma Progression

27 Feb 2017

Abstract excerpt

Human uveal melanoma (UM) is a major ocular malignant tumor with high risk of metastasis and requires multiple oncogenic factors for progression. ZEB1 is a zinc finger E-box binding transcription factor known for participating epithelial-mesenchymal transition (EMT), a critical cellular event for metastasis of malignant tumors of epithelium origin. ZEB1 is also expressed in UM and high expression of ZEB1...

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PMID: 28246385
DOI: 10.1038/s41598-017-00079-x

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