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ZEB1: A Critical Regulator of Cell Plasticity, DNA Damage Response, and Therapy Resistance

19 Mar 2020

Abstract excerpt

The predominant way in which conventional chemotherapy kills rapidly proliferating cancer cells is the induction of DNA damage. However, chemoresistance remains the main obstacle to therapy effectivity. An increasing number of studies suggest that epithelial-to-mesenchymal transition (EMT) represents a critical process affecting the sensitivity of cancer cells to chemotherapy. Zinc finger E-box binding homeobox 1...

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PMID: 32266287
DOI: 10.3389/fmolb.2020.00036

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