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Article

Direct repression of cyclin D1 by SIP1 attenuates cell cycle progression in cells undergoing an epithelial mesenchymal transition.

Molecular biology of the cell - 1 Nov 2007

Mejlvang Jakob, Kriajevska Marina, Vandewalle Cindy, Chernova Tatyana, Sayan A Emre, Berx Geert, Mellon J Kilian, Tulchinsky Eugene

Abstract excerpt

Zinc finger transcription factors of the Snail/Slug and ZEB-1/SIP1 families control epithelial-mesenchymal transitions in development in cancer. Here, we studied SIP1-regulated mesenchymal conversion of epidermoid A431 cells. We found that concomitant with inducing invasive phenotype, SIP1 inhibited expression of cyclin D1 and induced hypophosphorylation of the Rb tumor suppressor protein. Repression of cyclin D1...

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Identifiers

PMID: 17855508
DOI: 10.1091/mbc.e07-05-0406
PMCID: PMC2043563

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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