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Article

Downregulation of TET1 Promotes Bladder Cancer Cell Proliferation and Invasion by Reducing DNA Hydroxymethylation of AJAP1

21 May 2020

Abstract excerpt

Ten-Eleven Translocation 1 (TET1) is a member of methylcytosine dioxygenase, which catalyzes 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) to promote the demethylation process. The dysregulated TET1 protein and 5hmC level were reported to either suppress or promote carcinogenesis in a cancer type dependent manner. Currently the role of TET1 in the development of urinary bladder cancer (UBC) and its...

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Share to Bladder and Urothelial Cancer Treatments
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Identifiers

PMID: 32528872
DOI: 10.3389/fonc.2020.00667

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