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PTTG1/ZEB1 Axis Regulates E-Cadherin Expression in Human Seminoma

5 Oct 2022

Abstract excerpt

(1) Background: PTTG1 sustains the EMT process and the invasiveness of several neoplasms. We previously showed the role of nuclear PTTG1 in promoting invasiveness, through its transcriptional target MMP2, in seminoma in vitro models. Here, we investigated the key players involved in PTTG1-mediated EMT in human seminoma. (2) Methods: Two seminoma cell lines and four human seminoma tumor specimens were used....

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PMID: 36230799
DOI: 10.3390/cancers14194876

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