Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SIP1/ZEB2 induces EMT by repressing genes of different epithelial cell-cell junctions.

Nucleic acids research - 1 Jan 2005

Vandewalle Cindy, Comijn Joke, De Craene Bram, Vermassen Petra, Bruyneel Erik, Andersen Henriette, Tulchinsky Eugene, Van Roy Frans, Berx Geert

Abstract excerpt

SIP1/ZEB2 is a member of the deltaEF-1 family of two-handed zinc finger nuclear factors. The expression of these transcription factors is associated with epithelial mesenchymal transitions (EMT) during development. SIP1 is also expressed in some breast cancer cell lines and was detected in intestinal gastric carcinomas, where its expression is inversely correlated with that of E-cadherin. Here, we show that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cadherins
Share to Chromatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Connexins

Share to Down-Regulation

Share to Epithelial Cells

Share to Homeodomain Proteins

Share to Intercellular Junctions

Share to Mesoderm

Source

Open in PubMed Open full text

Identifiers

PMID: 16314317
DOI: 10.1093/nar/gki965
PMCID: PMC1298926

Genes

ZEB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SIP1/ZEB2 induces EMT by repressing genes of different epithelial cell-cell junctions.PMID 16314317Read ↗

Differential Regulation of Epithelial and Mesenchymal Markers by δEF1 Proteins in Epithelial–Mesenchymal Transition Induced by TGF-βSemantic proximity Read ↗

Direct repression of cyclin D1 by SIP1 attenuates cell cycle progression in cells undergoing an epithelial mesenchymal transition.Semantic proximity Read ↗

SIP1 protein protects cells from DNA damage-induced apoptosis and has independent prognostic value in bladder cancer.Semantic proximity Read ↗

Ets1 and ESE1 reciprocally regulate expression of ZEB1/ZEB2, dependent on ERK1/2 activity, in breast cancer cellsSemantic proximity Read ↗

Regulation of ZEB1 Function and Molecular Associations in Tumor Progression and MetastasisSemantic proximity Read ↗

TGF-β drives epithelial-mesenchymal transition through δEF1-mediated downregulation of ESRP.Semantic proximity Read ↗

Interaction between Smad-interacting protein-1 and the corepressor C-terminal binding protein is dispensable for transcriptional repression of E-cadherin.Semantic proximity Read ↗

The role of the ZEB family of transcription factors in development and disease.Semantic proximity Read ↗

Differential expression of the epithelial-mesenchymal transition regulators snail, SIP1, and twist in gastric cancer.Semantic proximity Read ↗

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1.Semantic proximity Read ↗

Zmiz1 is a novel regulator of lymphatic endothelial cell gene expression and functionSemantic proximity Read ↗

Integrative genomic analyses of ZEB2: Transcriptional regulation of ZEB2 based on SMADs, ETS1, HIF1α, POU/OCT, and NF-κBSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.