Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A glucocorticoid-resistant rat hepatoma cell variant contains functional glucocorticoid receptor.

The Journal of biological chemistry - 5 May 1990

Dong Y, Cairns W, Okret S, Gustafsson J A

Abstract excerpt

The mechanism of glucocorticoid resistance was studied in a rat hepatoma cell variant (6.10.2) which contains low levels of glucocorticoid receptor. These cells seem to have lost glucocorticoid-induced transcriptional responses as measured by the induction of expression of stably integrated mouse mammary tumor virus gene and the endogenous tyrosine aminotransferase gene, as well as the transcriptional suppression...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Variation
Share to Base Sequence
Share to Cell Line

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA, Neoplasm

Share to Molecular Sequence Data

Share to Promoter Regions, Genetic

Share to RNA, Messenger

Source

Identifiers

PMID: 1970570

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A glucocorticoid-resistant rat hepatoma cell variant contains functional glucocorticoid receptor.PMID 1970570Read ↗

Characterization of a steroid hormone receptor gene and mRNA in wild-type and mutant cells.Semantic proximity Read ↗

Cloning and expression of mutant glucocorticoid receptors from glucocorticoid-sensitive and -resistant human leukemic cells.Semantic proximity Read ↗

Lymphoma cell variants of decreased glucocorticoid sensitivity.Semantic proximity Read ↗

Evidence that glucocorticoid- and cyclic AMP-induced apoptotic pathways in lymphocytes share distal events.Semantic proximity Read ↗

Glucocorticoid-induced cell death requires autoinduction of glucocorticoid receptor expression in human leukemic T cells.Semantic proximity Read ↗

Steroid mediated lysis of lymphoblasts requires the DNA binding region of the steroid hormone receptor.Semantic proximity Read ↗

Biochemical evidence that glucocorticoid-sensitive cell lines derived from the human leukemic cell line CCRF-CEM express a normal and a mutant glucocorticoid receptor gene.Semantic proximity Read ↗

Resistance to glucocorticoid-induced apoptosis in human T-cell acute lymphoblastic leukemia CEM-C1 cells is due to insufficient glucocorticoid receptor expression.Semantic proximity Read ↗

A mechanism of resistance to glucocorticoids in multiple myeloma: transient expression of a truncated glucocorticoid receptor mRNA.Semantic proximity Read ↗

Hormone-dependent phosphorylation of the glucocorticoid receptor occurs mainly in the amino-terminal transactivation domain.Semantic proximity Read ↗

An optimum dose of c-H-ras is a prerequisite for hormone-dependent conversion of a cell between cancerous and normal states in tissue culture.Semantic proximity Read ↗

A mechanism of resistance to glucocorticoids in multiple myeloma: transient expression of a truncated glucocorticoid receptor mRNASemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.