A glucocorticoid-resistant rat hepatoma cell variant contains functional glucocorticoid receptor.

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Article

A glucocorticoid-resistant rat hepatoma cell variant contains functional glucocorticoid receptor.

The Journal of biological chemistry - 5 May 1990

Dong Y, Cairns W, Okret S, Gustafsson J A

Abstract excerpt

The mechanism of glucocorticoid resistance was studied in a rat hepatoma cell variant (6.10.2) which contains low levels of glucocorticoid receptor. These cells seem to have lost glucocorticoid-induced transcriptional responses as measured by the induction of expression of stably integrated mouse mammary tumor virus gene and the endogenous tyrosine aminotransferase gene, as well as the transcriptional suppression...

Topics

Animals
Base Sequence
Cell Line
Cell Transformation, Viral
Chromatography, Affinity
Cytosol
DNA, Neoplasm
Dexamethasone
Drug Resistance
Genetic Variation
Liver Neoplasms, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mammary Tumor Virus, Mouse

Molecular Sequence Data

Oligonucleotide Probes

Promoter Regions, Genetic

RNA, Messenger

Rats

Receptors, Glucocorticoid

Source

Open in PubMed

Identifiers

PMID: 1970570

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1970570-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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