Article
Characterization of a steroid hormone receptor gene and mRNA in wild-type and mutant cells.
Nature - 1 Jan 2000
Miesfeld R, Okret S, Wikström A C, Wrange O, Gustafsson J A, Yamamoto K R
Abstract excerpt
The effects of steroid hormones are mediated by intracellular hormone-specific receptor proteins; the interaction between the hormone and its receptor increases the affinity of the receptor for nuclear binding sites, thereby modulating the expression of specific genes. The glucocorticoid receptor is a soluble protein of relative molecular mass (Mr) 94,000 (94K), present at a low relative abundance (less than or...
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