Article
Lymphoma cell variants of decreased glucocorticoid sensitivity.
Molecular and cellular endocrinology - 1 Jan 2000
Gehring U, Ulrich J, Segnitz B
Abstract excerpt
Glucocorticoid-sensitive S49.1 mouse lymphoma cells were mutagenized and cloned in soft agar containing 10 nM dexamethasone. A series of clones were grown and tested for growth inhibition by dexamethasone. While most clones were completely resistant to the steroid, some were sensitive but required significantly higher glucocorticoid concentrations for the same response than wild-type cells. Two of these...
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