Article
Lymphoma cell variants of decreased glucocorticoid sensitivity.
Molecular and cellular endocrinology - 1 Jan 2000
Gehring U, Ulrich J, Segnitz B
Abstract excerpt
Glucocorticoid-sensitive S49.1 mouse lymphoma cells were mutagenized and cloned in soft agar containing 10 nM dexamethasone. A series of clones were grown and tested for growth inhibition by dexamethasone. While most clones were completely resistant to the steroid, some were sensitive but require...
Topics
- Animals
- Cell Division
- Cell Line
- Clone Cells
- Dexamethasone
- Dose-Response Relationship, Drug
- Karyotyping
- Lymphoma
- Mice
- Mutation
- Neoplasms, Experimental
- Receptors, Glucocorticoid
- Receptors, Steroid