A mechanism of resistance to glucocorticoids in multiple myeloma: transient expression of a truncated glucocorticoid receptor mRNA.

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Article

A mechanism of resistance to glucocorticoids in multiple myeloma: transient expression of a truncated glucocorticoid receptor mRNA.

Blood - 1 Jan 1992

Moalli P A, Pillay S, Weiner D, Leikin R, Rosen S T

Abstract excerpt

Despite their widespread use, little is known of either the mechanism of action of glucocorticoids in the treatment of multiple myeloma or why patients ultimately become resistant to their therapeutic effects. Here, we address these issues by examining the direct effects of the glucocorticoid dex...

Topics

Adult
Blotting, Southern
Cell Survival
Dexamethasone
Drug Resistance
Female
Gene Expression
Glucocorticoids
Humans
Mifepristone
Multiple Myeloma
Phenotype
RNA, Messenger
Receptors, Glucocorticoid
Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 1728309

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1728309-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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