Article

A mechanism of resistance to glucocorticoids in multiple myeloma: transient expression of a truncated glucocorticoid receptor mRNA

1992-01-01

Abstract excerpt

Abstract Despite their widespread use, little is known of either the mechanism of action of glucocorticoids in the treatment of multiple myeloma or why patients ultimately become resistant to their therapeutic effects. Here, we address these issues by examining the direct effects of the glucocorticoid dexamethasone (DEX) on a hormone-sensitive clone (MM.1S) of a human multiple myeloma line and compare them with th...

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Literature Corpus work: b2179476-bc6e-5b21-a4ed-4a9bd332270d
DOI: 10.1182/blood.v79.1.213.213

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