Steroid mediated lysis of lymphoblasts requires the DNA binding region of the steroid hormone receptor.

doi:10.1016/0022-4731(90)90137-h

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Article

Steroid mediated lysis of lymphoblasts requires the DNA binding region of the steroid hormone receptor.

Journal of steroid biochemistry - 1 Jan 1990

Harbour D V, Chambon P, Thompson E B

Abstract excerpt

Glucocorticoids kill certain types of lymphoblasts, but the mechanisms are unknown. It is clear that sufficient numbers of functional glucocorticoid receptors are required to mediate lysis, but whether they do so through the classical model of steroid hormone activation and modulation of gene exp...

Topics

Binding Sites
Cell Survival
DNA
Dexamethasone
Enzyme Induction
Glutamate-Ammonia Ligase
Humans
Leukemia
Lymphocytes
Mutation
Receptors, Glucocorticoid
Transfection
Tumor Cells, Cultured

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