Article
Steroid mediated lysis of lymphoblasts requires the DNA binding region of the steroid hormone receptor.
Journal of steroid biochemistry - 1 Jan 1990
Harbour D V, Chambon P, Thompson E B
Abstract excerpt
Glucocorticoids kill certain types of lymphoblasts, but the mechanisms are unknown. It is clear that sufficient numbers of functional glucocorticoid receptors are required to mediate lysis, but whether they do so through the classical model of steroid hormone activation and modulation of gene expression has not been established. In this report we have asked which region(s) of the steroid receptor are important...
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