Evidence that glucocorticoid- and cyclic AMP-induced apoptotic pathways in lymphocytes share distal events.

doi:10.1128/mcb.12.8.3600-3608.1992

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Article

Evidence that glucocorticoid- and cyclic AMP-induced apoptotic pathways in lymphocytes share distal events.

Molecular and cellular biology - 1 Aug 1992

Dowd D R, Miesfeld R L

Abstract excerpt

WEHI7.2 murine lymphocytes undergo apoptotic death when exposed to glucocorticoids or elevated levels of intracellular cyclic AMP (cAMP), and these pathways are initiated by the glucocorticoid receptor (GR) and protein kinase A, respectively. We report the isolation and characterization of a novel WEHI7.2 variant cell line, WR256, which was selected in a single step for growth in the presence of dexamethasone and...

Topics

8-Bromo Cyclic Adenosine Monophosphate
Animals
Blotting, Northern
Cell Cycle
Cell Death
Cell Line
Chloramphenicol O-Acetyltransferase
Cyclic AMP
Dexamethasone
Kinetics
Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mammary Tumor Virus, Mouse

Mice

Phenotype

Protein Kinases

RNA

Receptors, Glucocorticoid

Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 1378529
DOI: 10.1128/mcb.12.8.3600-3608.1992
PMCID: PMC364626

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1378529-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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