Article
Evidence that glucocorticoid- and cyclic AMP-induced apoptotic pathways in lymphocytes share distal events.
Molecular and cellular biology - 1 Aug 1992
Dowd D R, Miesfeld R L
Abstract excerpt
WEHI7.2 murine lymphocytes undergo apoptotic death when exposed to glucocorticoids or elevated levels of intracellular cyclic AMP (cAMP), and these pathways are initiated by the glucocorticoid receptor (GR) and protein kinase A, respectively. We report the isolation and characterization of a novel WEHI7.2 variant cell line, WR256, which was selected in a single step for growth in the presence of dexamethasone and...
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