Article
Resistance to glucocorticoid-induced apoptosis in human T-cell acute lymphoblastic leukemia CEM-C1 cells is due to insufficient glucocorticoid receptor expression.
Cancer research - 1 Nov 1996
Geley S, Hartmann B L, Hala M, Strasser-Wozak E M, Kapelari K, Kofler R
Abstract excerpt
The ability of glucocorticoids (GCs) to induce death in lymphoid-origin cells is the basis for their frequent use in the therapy of various human hematological malignancies. However, the occurrence of primary or secondary GC resistance limits their clinical usefulness. Prior investigations into t...
Topics
- Animals
- Apoptosis
- Drug Resistance
- Glucocorticoids
- Humans
- Leukemia-Lymphoma, Adult T-Cell
- Phenotype
- Rats
- Receptors, Glucocorticoid
- Tumor Cells, Cultured