Article
An optimum dose of c-H-ras is a prerequisite for hormone-dependent conversion of a cell between cancerous and normal states in tissue culture.
Cell biology international reports - 1 Jul 1991
Xu Z Z, Miyahara K, Liszczynsky H, Seno S, Naora H
Abstract excerpt
We have established a few cell lines which can be reversibly converted from cancerous to normal and vice versa by the addition to, or removal from the culture medium of glucocorticoid hormone. These cell lines were derived from mouse NIH 3T3 cells and possessed the integrated gene pairs on chromosomes, which are composed of human mutated c-H-ras fused with mouse mammary tumour virus long terminal repeat and E....
Topics
- Animals
- Cell Line, Transformed
- Cell Transformation, Neoplastic
- Dexamethasone
- Gene Amplification
- Genes, ras
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Mammary Tumor Virus, Mouse
- Mice