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Article

CYP46: a risk factor for Alzheimer's disease or a coincidence?

Neuroscience letters - 1 Jan 2000

Golanska Ewa, Hulas-Bigoszewska Krystyna, Wojcik Izabela, Rieske Piotr, Styczynska Maria, Peplonska Beata, Pfeffer Anna, Luczywek Elzbieta, Wasiak Boguslaw, Gabryelewicz Tomasz, Religa Dorota, Chodakowska-Zebrowska Malgorzata, Barcikowska Maria, Sobow Tomasz, Liberski Pawel P

Abstract excerpt

Excess cholesterol is removed from the brain via hydroxylation mediated by cholesterol 24S-hydroxylase (CYP46). Although serum and cerebrospinal fluid (CSF) concentrations of 24S-hydroxycholesterol are altered during the progress of Alzheimer's disease, studies carried out to date in different populations on the association of CYP46 gene polymorphisms and risk of AD have been inconclusive. In this report, we...

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Identifiers

PMID: 15936520
DOI: 10.1016/j.neulet.2005.03.049

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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