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Article

Genetic association of CYP46 and risk for Alzheimer's disease.

Dementia and geriatric cognitive disorders - 1 Jan 2004

Combarros Onofre, Infante Jon, Llorca Javier, Berciano José

Abstract excerpt

An increasing number of studies suggest that cholesterol plays an important role in regulating beta-amyloid (Abeta) metabolism in Alzheimer's disease (AD). One of the most important mechanisms for the elimination of excess brain cholesterol is its conversion into the 24S-hydroxycholesterol catalyzed by cholesterol 24S-hydroxylase (CYP46). Preliminary evidence indicates that an intron 2 CYP46 T/C gene...

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Identifiers

PMID: 15286456
DOI: 10.1159/000080025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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